Name: HIF-1 β/ARNT Monoclonal Antibody [4C5]
SKU: WM1169
Price: 268 USD
Availability: InStock

HIF-1 β/ARNT Monoclonal Antibody [4C5]

Ucallm_WM1169-50

Price range: $268.00 through $328.00

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SKU: WM1169-50

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Product details

Background:
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013],

Specifications

Size	50μL/100μL
Target	HIF-1β
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF
MW(Calculated)
MW(Observed)	87kD
Host Species	Mouse
Isotype	IgG1,kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-2000; IHC 1:100-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	4C5
Immunogen	Recombinant Protein of HIF-1 β
Specificity	HIF-1 β/ARNT protein detects endogenous levels of HIF-1 β/ARNT
Gene Name	ARNT
Protein Name	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Other Name	ARNT; / BHLHE2; / Aryl hydrocarbon receptor nuclear translocator; / ARNT protein; / Class E basic helix-loop-helix protein 2; / bHLHe2; / Dioxin receptor, nuclear translocator; / Hypoxia-inducible factor 1-beta; / HIF-1-beta; / HIF1-beta
Species	Human
Gene ID	405
Uniprot	P27540,
Species.1	Mouse
Gene ID.1
Uniprot.1	P53762,
Species.2	Rat
Gene ID.2
Uniprot.2	P41739
Cellular Localization	Nucleus.
Tissue Expression	Aorta endothelial cell,Brain,Kidney,Thalamus,Uterus,
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Renal cell carcinoma;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas	>>HIF-1 signaling pathway; / >>Cushing syndrome; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Chemical carcinogenesis - reactive oxygen species; / >>Renal cell carcinoma
Function	Function:Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7.,