SKU: WM0495 Categories: ,

Hip Monoclonal Antibody

Price range: $268.00 through $328.00

SKU: WM0495-50
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Product details

Background:
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013],

Specifications

Size50μL/100μL
TargetHip
ReactivityHuman, Bovine, Dog, Pig
ApplicationsWB, IHC, IF
MW(Calculated)41kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number14D3
ImmunogenPurified recombinant human Hip protein fragments expressed in E.coli.
SpecificityHip Monoclonal Antibody detects endogenous levels of Hip protein.
Gene NameST13
Protein NameHsc70-interacting protein
Other NameST13; / AAG2; / FAM10A1; / HIP; / SNC6; / Hsc70-interacting protein; / Hip; / Aging-associated protein 2; / Progesterone receptor-associated p48 protein; / Protein FAM10A1; / Putative tumor suppressor ST13; / Renal carcinoma antigen NY-REN-33; / Suppression of tum
SpeciesHuman
Gene ID6767
UniprotP50502,
Species.1Mouse
Gene ID.1
Uniprot.1Q99L47
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm .
Tissue ExpressionColon mucosa,Epithelium,Fet
Signaling_pathway
Research Areas
FunctionFunction:One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.,similarity:Belongs to the FAM10 family.,similarity:Contains 1 STI1 domain.,similarity:Contains 3 TPR repeats.,subunit:Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90.,
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