U-Blot® Histone H3 (Acetyl Lys18) Rabbit pAb
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Price range: $288.00 through $368.00
Product details
Background:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],
Specifications
| Target | Histone H3 |
| Reactivity | Human,Mouse,Rat |
| Application | WB,IHC,IF,ELISA |
| MW(Calculated) | |
| MW(Observed) | 17kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Acetyl |
| Modification site | Lys18 |
| Recommended dilution ratio | WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Histone H3 around the acetylated site of Lys18. AA range:1-50 |
| Sequence | |
| Specificity | This antibody detects histone H2A.Z only when it is L-lactylated at Lys11. detects endogenous levels of Histone H3 protein only when acetylated at K18. |
| Gene name | HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J/HIST2H3A/HIST2H3C/HIST2H3D/H3F3A/H3F3B |
| Protein name | Histone H3.1/Histone H3.2/Histone H3.3 |
| Alternative name | HIST1H3A;H3FA;HIST1H3B;H3FL;HIST1H3C;H3FC;HIST1H3D;H3FB;HIST1H3E;H3FD;HIST1H3F;H3FI;HIST1H3G;H3FH;HIST1H3H;H3FK;HIST1H3I;H3FF;HIST1H3J;H3FJ;Histone H3.1;Histone H3/a;Histone H3/b;Histone H3/c;Histone H3/d;Histone H3;H3k18AC |
| Organism-1 | Human |
| Gene ID‑1 | 8350;8351;8352;8353;8354;8355;8356;8357;8358;8968;126961;333932;653604;3020;3021 |
| SwissProt-1 | P68431;Q71DI3;P84243 |
| Organism-2 | Mouse |
| Gene ID‑2 | 319152;15077;15078 |
| SwissProt-2 | |
| Organism-3 | Rat |
| Gene ID‑3 | 291159;100361558 |
| SwissProt-3 | Q6LED0;P84245 |
| Organism-4 | |
| Gene ID‑4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus. Chromosome. |
| Unnamed: 38 | |
| Unnamed: 39 |
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