Product details
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HMBS rabbit pAb
Ucallm_WP8806-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | HMBS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 40kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human HMBS |
| Specificity | This antibody detects endogenous levels of HMBS at Human, Mouse,Rat |
| Gene Name | HMBS PBGD UPS |
| Protein Name | Porphobilinogen deaminase (PBG-D) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) |
| Other Name | |
| Species | Human |
| Gene ID | 3145 |
| Uniprot | P08397, |
| Species.1 | Mouse |
| Gene ID.1 | 15288 |
| Uniprot.1 | P22907, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P19356 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | [Isoform 1]: Is ubiquitously expressed.; [Isoform 2]: Is found only in erythroid cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen . Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact . |
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