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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/HMGA1 Polyclonal Antibody
SKU: WP3271 Categories: ,

HMGA1 Polyclonal Antibody

Ucallm_WP3271-50

Price range: $268.00 through $328.00

SKU: WP3271-100
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Product details

Background:

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016],

Specifications

Size50μL/100μL
TargetHMGA1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)11kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein AA range: 1-50
SpecificityHMGA1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameHMGA1 HMGIY
Protein NameHigh mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R)
Other NameHigh mobility group protein HMG-I/HMG-Y; / HMG-I; / Y; / High mobility group AT-hook protein 1; / High mobility group protein A1; / High mobility group protein R
SpeciesHuman
Gene ID3159
UniprotP17096,
Species.1Mouse
Gene ID.1111241
Uniprot.1P17095,
Species.2Rat
Gene ID.2117062
Uniprot.2Q8K585
Cellular LocalizationNucleus. Chromosome.
Tissue ExpressionB-cell,Colon,Epithelium,Kidney,Liver,Mammary gland,Muscle,Pancreas,Placenta
Signaling_pathway
Research Areas
FunctionDisease:A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6; 14)(p21; q23-24) with RAD51L1.,Function:HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.,mass spectrometry:With 1 acetyl and 2 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl and 3 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 1 methyl and 2 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 1 methyl and 3 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 2 methyl and 2 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 2 methyl and 3 phosphate groups PubMed:15302935,PTM:Constitutively phosphorylated on two or three sites. Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoform HMG-Y can be phosphorylated by HIPK2.,PTM:HMG-Y is not methylated.,PTM:Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.,similarity:Belongs to the HMGA family.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.,
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