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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/HSF4 Polyclonal Antibody
SKU: WP0584 Categories: ,

HSF4 Polyclonal Antibody

Ucallm_WP0584-50

Price range: $268.00 through $328.00

SKU: WP0584-100
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Product details

Background:

heat shock transcription factor 4(HSF4) Homo sapiens Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetHSF4
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)54kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 290-370
SpecificityHSF4 Polyclonal Antibody detects endogenous levels of protein.
Gene NameHSF4
Protein NameHeat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)
Other Name
SpeciesHuman
Gene ID3299
UniprotQ9ULV5,
Species.1Mouse
Gene ID.1
Uniprot.1Q9R0L1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus .
Tissue ExpressionExpressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
Signaling_pathway
Research Areas
FunctionDisease:Defects in HSF4 are the cause of lamellar cataract [MIM:116800]; also known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds.,Function:DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.,PTM:Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-299. HSFA is not sumoylated.,PTM:Phosphorylated mainly on serine residues. Phosphorylation on Ser-299 promotes sumoylation on Lys-294.,similarity:Belongs to the HSF family.,subunit:Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with DUSP26, MAPK1, MAPK2 and MAP kinase p38.,tissue specificity:Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.,
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