Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012],
| Size | 50μL/100μL |
| Target | HSP β2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 24kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HSPB2. AA range:121-170 |
| Specificity | HSP β2 Polyclonal Antibody detects endogenous levels of HSP β2 protein. |
| Gene Name | HSPB2 |
| Protein Name | Heat shock protein beta-2 |
| Other Name | HSPB2; / Heat shock protein beta-2; / HspB2; / DMPK-binding protein; / MKBP |
| Species | Human |
| Gene ID | 3316 |
| Uniprot | Q16082, |
| Species.1 | Mouse |
| Gene ID.1 | 69253 |
| Uniprot.1 | Q99PR8, |
| Species.2 | Rat |
| Gene ID.2 | 161476 |
| Uniprot.2 | O35878 |
| Cellular Localization | Cytoplasm . Nucleus . Localizes to nuclear foci. |
| Tissue Expression | Expressed preferentially in skeletal muscle and heart but not in the lens. |
| Signaling_pathway | |
| Research Areas | >>Proteoglycans in cancer |
| Function | similarity:Belongs to the small heat shock protein (HSP20) family.,subunit:Associates specifically with myotonic dystrophy protein kinase (DMPK).,tissue specificity:Expressed preferentially in skeletal muscle and heart but not in the lens., |
