Name: HSP60 Polyclonal Antibody
SKU: WP12763
Price: 268 USD
Availability: InStock

HSP60 Polyclonal Antibody

Ucallm_WP12763-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12763-100

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Product details

Background:

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010],

Specifications

Size	50μL/100μL
Target	Hsp60
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	68kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human HSP60. AA range:511-560
Specificity	HSP60 Polyclonal Antibody detects endogenous levels of HSP60 protein.
Gene Name	HSPD1
Protein Name	60 kDa heat shock protein mitochondrial
Other Name	HSPD1; / HSP60; / 60 kDa heat shock protein; / mitochondrial; / 60 kDa chaperonin; / Chaperonin 60; / CPN60; / Heat shock protein 60; / HSP-60; / Hsp60; / HuCHA60; / Mitochondrial matrix protein P1; / P60 lymphocyte protein
Species	Human
Gene ID	3329
Uniprot	P10809,
Species.1	Mouse
Gene ID.1	15510
Uniprot.1	P63038,
Species.2	Rat
Gene ID.2	63868
Uniprot.2	P63039
Cellular Localization	Mitochondrion matrix.
Tissue Expression	Adipocyte,Adrenal gland,B-cell lymphoma,Brain,Cajal-Retzius
Signaling_pathway	Genetic Information Processing >> Folding, sorting and degradation >> RNA degradation
Research Areas	>>RNA degradation; / >>Type I diabetes mellitus; / >>Legionellosis; / >>Tuberculosis; / >>Lipid and atherosclerosis
Function	Disease:Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,Disease:Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first 2 decades of life.,Function:Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.,similarity:Belongs to the chaperonin (HSP60) family.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Interacts with HBV protein X and HTLV-1 protein p40tax.,