Name: HSP90β Monoclonal Antibody
SKU: WM0242
Price: 268 USD
Availability: InStock

Product details

Background:
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],

Specifications

Size	50μL/100μL
Target	HSP90β
Reactivity	Human, Mouse, Rat, Monkey
Applications	WB, IHC, IF, FC, ELISA
MW(Calculated)	83kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	17F4
Immunogen	Purified recombinant fragment of human HSP90β expressed in E. Coli.
Specificity	HSP90β Monoclonal Antibody detects endogenous levels of HSP90β protein.
Gene Name	HSP90AB1
Protein Name	Heat shock protein HSP 90-beta
Other Name	HSP90AB1; / HSP90B; / HSPC2; / HSPCB; / Heat shock protein HSP 90-beta; / HSP 90; / Heat shock 84 kDa; / HSP 84; / HSP84
Species	Human
Gene ID	3326
Uniprot	P08238,
Species.1	Mouse
Gene ID.1	15516
Uniprot.1	P11499,
Species.2	Rat
Gene ID.2	301252
Uniprot.2	P34058
Cellular Localization	Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). .
Tissue Expression	Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas	>>Protein processing in endoplasmic reticulum; / >>PI3K-Akt signaling pathway; / >>Necroptosis; / >>Antigen processing and presentation; / >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Th17 cell differentiation; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Salmonella infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Prostate cancer; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis
Function	Function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,

Please login to post questions

HSP90β Monoclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

HSP90β Monoclonal Antibody

Product details

Specifications

Related products

U-Blot® α smooth muscle actin Rabbit mAb

U-Blot™ SSPE buffer, pH 7.4

U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

U-Blot® NQO1 Rabbit mAb

U-Blot® Cyclin B1 (Phospho Ser126) Rabbit mAb

U-Blot® FOXO3A (Phospho Ser253) Rabbit mAb

Customer Reviews

Menu