Name: HSP90β Polyclonal Antibody
SKU: WP12755
Price: 268 USD
Availability: InStock

Product details

Background:

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],

Specifications

Size	50μL/100μL
Target	HSP90β
Reactivity	Human, Mouse, Rat, Monkey
Applications	WB, IHC, IP, IF, ELISA
MW(Calculated)
MW(Observed)	90kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IP 2-5 ug/mg lysate; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human HSP90B. AA range:226-275
Specificity	HSP90β Polyclonal Antibody detects endogenous levels of HSP90β protein.
Gene Name	HSP90AB1
Protein Name	Heat shock protein HSP 90-beta
Other Name	HSP90AB1; / HSP90B; / HSPC2; / HSPCB; / Heat shock protein HSP 90-beta; / HSP 90; / Heat shock 84 kDa; / HSP 84; / HSP84
Species	Human
Gene ID	3326
Uniprot	P08238,
Species.1	Mouse
Gene ID.1	15516
Uniprot.1	P11499,
Species.2	Rat
Gene ID.2	301252
Uniprot.2	P34058
Cellular Localization	Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). .
Tissue Expression	Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas	>>Protein processing in endoplasmic reticulum; / >>PI3K-Akt signaling pathway; / >>Necroptosis; / >>Antigen processing and presentation; / >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Th17 cell differentiation; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Salmonella infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Prostate cancer; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis
Function	Function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,