I-FABP Polyclonal Antibody
Ucallm_WP15818-50
Price range: $268.00 through $328.00
Product details
Background:
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | I-FABP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 15kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 90-132 |
| Specificity | The antibody detects endogenous I-FABP |
| Gene Name | FABP2 FABPI |
| Protein Name | Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP) |
| Other Name | Fatty acid-binding protein, intestinal; / Fatty acid-binding protein 2; / Intestinal-type fatty acid-binding protein; / I-FABP |
| Species | Human |
| Gene ID | 2169 |
| Uniprot | P12104, |
| Species.1 | Mouse |
| Gene ID.1 | 14079 |
| Uniprot.1 | P55050, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P02693 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>PPAR signaling pathway; / >>Fat digestion and absorption |
| Function | Domain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,Function:FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.,induction:By EGF.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,tissue specificity:Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum., |
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