Price range: $268.00 through $328.00
Background:
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016],
| Size | 50μL/100μL |
| Target | AIF1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 16kD |
| MW(Observed) | 17kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1347 |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 50-147 |
| Specificity | This antibody detects endogenous levels of Iba 1 protein. |
| Gene Name | AIF1 G1 IBA1 |
| Protein Name | Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1) |
| Other Name | AIF 1; / AIF-1; / Aif1; / AIF1 protein; / AIF1_HUMAN; / Allograft inflammatory factor 1; / Allograft inflammatory factor 1 splice variant G; / allograft inflammatory factor-1 splice variant Hara-1; / balloon angioplasty responsive transcription; / BART 1; / G1; / G1 putative splice variant of allograft inflamatory factor 1; / IBA 1; / IBA1; / interferon gamma responsive transcript; / Interferon responsive transcript 1; / interferon responsive transcript factor 1; / Ionized calcium binding adapter molecule 1; / Ionized calcium-binding adapter molecule 1; / ionized calcium-binding adapter molecule; / IRT 1; / IRT1; / Microglia response factor; / MRF1; / Protein g1 |
| Species | Human |
| Gene ID | 199 |
| Uniprot | P55008, |
| Species.1 | Mouse |
| Gene ID.1 | 11629 |
| Uniprot.1 | O70200, |
| Species.2 | Rat |
| Gene ID.2 | 29427 |
| Uniprot.2 | P55009 |
| Cellular Localization | Membranous |
| Tissue Expression | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May play a role in macrophage activation and function.,PTM:Phosphorylated on serine residues.,similarity:Contains 2 EF-hand domains., |
