Product details
Background:
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011],
IFN-α1 Polyclonal Antibody
Ucallm_WP15249-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | IFN-α1 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human IFNA1/13. AA range:140-189 |
| Specificity | IFN-α1 Polyclonal Antibody detects endogenous levels of IFN-α1 protein. |
| Gene Name | IFNA1/IFNA13 |
| Protein Name | Interferon alpha-1/13 |
| Other Name | IFNA1; / IFNA13; / Interferon alpha-1/13; / IFN-alpha-1/13; / Interferon alpha-D; / LeIF D |
| Species | Human |
| Gene ID | 3439 |
| Uniprot | P01562, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P01572 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Cerebellum,Leukocyte, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>PI3K-Akt signaling pathway; / >>Necroptosis; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway; / >>JAK-STAT signaling pathway; / >>Natural killer cell mediated cytotoxicity; / >>Alcoholic liver disease; / >>Tuberculosis; / >>Hepatitis C; / >>Hepatitis B; / >>Measles; / >>Human cytomegalovirus infection; / >>Influenza A; / >>Human papillomavirus infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Autoimmune thyroid disease; / >>Lipid and atherosclerosis |
| Function | Function:Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.,miscellaneous:Interferons alpha-1 and alpha-13 have identical protein sequences.,polymorphism:Two forms exist; alpha-1a (shown here) and alpha-1b.,similarity:Belongs to the alpha/beta interferon family., |
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