IL-1α Monoclonal Antibody
Ucallm_WM0260-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | IL-1α |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 31kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 9F11 |
| Immunogen | Purified recombinant fragment of human IL-1a expressed in E. Coli. |
| Specificity | IL-1α Monoclonal Antibody detects endogenous levels of IL-1α protein. |
| Gene Name | IL1A |
| Protein Name | Interleukin-1 alpha |
| Other Name | IL1A; / IL1F1; / Interleukin-1 alpha; / IL-1 alpha; / Hematopoietin-1 |
| Species | Human |
| Gene ID | 3552 |
| Uniprot | P01583, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P01582 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). . |
| Tissue Expression | Lung, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Graft-versus-host disease;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>MAPK signaling pathway; / >>Cytokine-cytokine receptor interaction; / >>Necroptosis; / >>Cellular senescence; / >>Osteoclast differentiation; / >>Hematopoietic cell lineage; / >>Non-alcoholic fatty liver disease; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Type I diabetes mellitus; / >>Alzheimer disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Pertussis; / >>Leishmaniasis; / >>Tuberculosis; / >>Measles; / >>Influenza A; / >>Inflammatory bowel disease; / >>Rheumatoid arthritis; / >>Graft-versus-host disease; / >>Fluid shear stress and atherosclerosis |
| Function | Domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,Function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer., |
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