Name: IL-1β [PTR2541] mouse mAb
SKU: WM1331
Price: 268 USD
Availability: InStock

Product details

Background:
interleukin 1 beta(IL1B) Homo sapiens The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IL-1β
Reactivity	Human, Mouse, Rat
Applications	WB, IF, ELISA
MW(Calculated)	31kD
MW(Observed)	31kD,18kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMMR2541
Immunogen	Synthesized peptide derived from human IL-1β AA range: 150-250
Specificity	This antibody detects endogenous levels of IL-1β protein.
Gene Name	IL1B IL1F2
Protein Name	Interleukin-1 beta (IL-1 beta) (Catabolin)
Other Name	IL1B; / IL1F2; / Interleukin-1 beta; / IL-1 beta; / Catabolin
Species	Human
Gene ID	3553
Uniprot	P01584,
Species.1	Mouse
Gene ID.1	16176
Uniprot.1	P10749,
Species.2	Rat
Gene ID.2
Uniprot.2	Q63264
Cellular Localization
Tissue Expression	Expressed in activated monocytes/macrophages (at protein level).
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Graft-versus-host disease;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Antifolate resistance; / >>MAPK signaling pathway; / >>Cytokine-cytokine receptor interaction; / >>NF-kappa B signaling pathway; / >>Necroptosis; / >>Osteoclast differentiation; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway; / >>C-type lectin receptor signaling pathway; / >>Hematopoietic cell lineage; / >>IL-17 signaling pathway; / >>Th17 cell differentiation; / >>TNF signaling pathway; / >>Inflammatory mediator regulation of TRP channels; / >>Non-alcoholic fatty liver disease; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Alcoholic liver disease; / >>Type I diabetes mellitus; / >>Alzheimer disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Pertussis; / >>Legionellosis; / >>Yersinia infection; / >>Leishmaniasis; / >>Chagas disease; / >>African trypanosomiasis; / >>Malaria; / >>Amoebiasis; / >>Tuberculosis; / >>Measles; / >>Human cytomegalovirus infection; / >>Influenza A; / >>Herpes simplex virus 1 infection; / >>Coronavirus disease - COVID-19; / >>Inflammatory bowel disease; / >>Rheumatoid arthritis; / >>Graft-versus-host disease; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis
Function	Domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,Function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer.,

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IL-1β [PTR2541] mouse mAb

Product details

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IL-1β [PTR2541] mouse mAb

Product details

Specifications

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