IL-11 Polyclonal Antibody
Ucallm_WP12804-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012],
Specifications
| Size | 50μL/100μL |
| Target | IL-11 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 21kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL-11. AA range:27-76 |
| Specificity | IL-11 Polyclonal Antibody detects endogenous levels of IL-11 protein. |
| Gene Name | IL11 |
| Protein Name | Interleukin-11 |
| Other Name | IL11; / Interleukin-11; / IL-11; / Adipogenesis inhibitory factor; / AGIF; / Oprelvekin |
| Species | Human |
| Gene ID | 3589 |
| Uniprot | P20809, |
| Species.1 | Mouse |
| Gene ID.1 | 16156 |
| Uniprot.1 | P47873, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q99MF5 |
| Cellular Localization | Secreted . |
| Tissue Expression | Bone marrow,Prostate, |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage; / >>Rheumatoid arthritis |
| Function | Function:Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.,online information:Clinical information on Neumega,online information:Interleukin-11 entry,pharmaceutical:Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.,similarity:Belongs to the IL-6 superfamily., |
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