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IL-12A p35 Polyclonal Antibody
Ucallm_WP15473-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | IL-12A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL12A. AA range:31-80 |
| Specificity | IL-12A p35 Polyclonal Antibody detects endogenous levels of IL-12A p35 protein. |
| Gene Name | IL12A |
| Protein Name | Interleukin-12 subunit alpha |
| Other Name | IL12A; / NKSF1; / Interleukin-12 subunit alpha; / IL-12A; / Cytotoxic lymphocyte maturation factor 35 kDa subunit; / CLMF p35; / IL-12 subunit p35; / NK cell stimulatory factor chain 1; / NKSF1 |
| Species | Human |
| Gene ID | 3592 |
| Uniprot | P29459, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P43431 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Brain,Placenta, |
| Signaling_pathway | Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Allograft rejection;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Toll-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>C-type lectin receptor signaling pathway; / >>JAK-STAT signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Alcoholic liver disease; / >>Type I diabetes mellitus; / >>Pertussis; / >>Legionellosis; / >>Leishmaniasis; / >>Chagas disease; / >>African trypanosomiasis; / >>Malaria; / >>Toxoplasmosis; / >>Amoebiasis; / >>Tuberculosis; / >>Measles; / >>Influenza A; / >>Herpes simplex virus 1 infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Inflammatory bowel disease; / >>Allograft rejection; / >>Lipid and atherosclerosis |
| Function | Function:Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.,online information:Interleukin-12 entry,similarity:Belongs to the IL-6 superfamily.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12., |
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