Price range: $268.00 through $328.00
Background:
function:Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts., online information:Interleukin-17 entry, PTM:Found both in glycosylated and nonglycosylated forms., similarity:Belongs to the IL-17 family., subunit:Homodimer., tissue specificity:Restricted to activated memory T-cells.,
| Target | IL17 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, FC, ELISA |
| MW(Calculated) | 17kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; Flow Cyt 1:50-200; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human IL-17 AA range: 50-100 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of Human IL-17 |
| Gene Name | IL17A CTLA8 IL17 |
| Protein Name | IL-17 |
| Other Name | Interleukin-17A; / IL-17; / IL-17A; / Cytotoxic T-lymphocyte-associated antigen 8; / CTLA-8 |
| Species | Human |
| Gene ID-1 | 3605 |
| Uniprot | Q16552, |
| Species.1 | Mouse |
| Gene ID-2 | 16171 |
| Uniprot.1 | Q62386, |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | Q61453 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | function:Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.,online information:Interleukin-17 entry,PTM:Found both in glycosylated and nonglycosylated forms.,similarity:Belongs to the IL-17 family.,subunit:Homodimer.,tissue specificity:Restricted to activated memory T-cells., |
| Cellular Localization | Secreted . |
| Tissue Expression | Expressed in memory Th17 cells (at protein level). |
| Signaling_pathway | Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Inflammatory bowel disease;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>IL-17 signaling pathway; / >>Th17 cell differentiation; / >>Alcoholic liver disease; / >>Inflammatory bowel disease; / >>Rheumatoid arthritis |
| Function | regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid glycosylation, apoptosis, defense response, inflammatory response, immune response, cell-cell signaling,cell death, glycoprotein metabolic process, glycoprotein biosynthetic process, response to wounding, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, programmed cell death, death, positive regulation of cellular biosynthetic process, biopolymer glycosylation, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter,positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, glycosylation, |
| RRID |
