IL-1RII Polyclonal Antibody
Ucallm_WP15498-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012],
Specifications
| Size | 50μL/100μL |
| Target | IL-1RII |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL1R2. AA range:141-190 |
| Specificity | IL-1RII Polyclonal Antibody detects endogenous levels of IL-1RII protein. |
| Gene Name | IL1R2 |
| Protein Name | Interleukin-1 receptor type 2 |
| Other Name | IL1R2; / IL1RB; / Interleukin-1 receptor type 2; / IL-1R-2; / IL-1RT-2; / IL-1RT2; / CD121 antigen-like family member B; / CDw121b; / IL-1 type II receptor; / Interleukin-1 receptor beta; / IL-1R-beta; / Interleukin-1 receptor type II; / CD121b |
| Species | Human |
| Gene ID | 7850 |
| Uniprot | P27930, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P27931 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform Short]: Secreted .; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | B-cell,Colon,Ovary, |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Hematopoietic cell lineage; / >>Amoebiasis; / >>Human T-cell leukemia virus 1 infection; / >>Transcriptional misregulation in cancer; / >>Prostate cancer; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1ra).,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., |
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