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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/IL-20Rα Polyclonal Antibody
SKU: WP12817 Categories: ,

IL-20Rα Polyclonal Antibody

Ucallm_WP12817-50

Price range: $268.00 through $328.00

SKU: WP12817-100
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Product details

Background:

This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetIL-20Rα
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)62kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human IL-20Ralpha. AA range:173-222
SpecificityIL-20Rα Polyclonal Antibody detects endogenous levels of IL-20Rα protein.
Gene NameIL20RA
Protein NameInterleukin-20 receptor subunit alpha
Other NameIL20RA; / Interleukin-20 receptor subunit alpha; / IL-20 receptor subunit alpha; / IL-20R-alpha; / IL-20RA; / Cytokine receptor class-II member 8; / Cytokine receptor family 2 member 8; / CRF2-8; / IL-20R1; / ZcytoR7
SpeciesHuman
Gene ID53832
UniprotQ9UHF4,
Species.1Mouse
Gene ID.1
Uniprot.1Q6PHB0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein .
Tissue ExpressionWidely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>JAK-STAT signaling pathway
FunctionFunction:The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer with IL20RB and heterodimer with IL10RB.,tissue specificity:Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.,
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