Product details
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INADL rabbit pAb
Ucallm_WP8975-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | PATJ |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 198kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human INADL |
| Specificity | This antibody detects endogenous levels of INADL at Human, Mouse |
| Gene Name | INADL PATJ |
| Protein Name | InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions) |
| Other Name | |
| Species | Human |
| Gene ID | 10207 |
| Uniprot | Q8NI35, |
| Species.1 | Mouse |
| Gene ID.1 | 12695 |
| Uniprot.1 | Q63ZW7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell junction, tight junction . Apical cell membrane; Peripheral membrane protein . Cytoplasm, perinuclear region . Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). . |
| Tissue Expression | Expressed in renal tubules (at protein level) (PubMed:19755384). Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway |
| Research Areas | |
| Function | Scaffolding protein that facilitates the localization of proteins to the cell membrane . Required for the correct formation of tight junctions and epithelial apico-basal polarity . Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries . |
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