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INPP4B rabbit pAb
Ucallm_WP9029-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | INPP4B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 102kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human INPP4B |
| Specificity | This antibody detects endogenous levels of INPP4B at Human, Mouse,Rat |
| Gene Name | INPP4B |
| Protein Name | Type II inositol 3,4-bisphosphate 4-phosphatase (Inositol polyphosphate 4-phosphatase type II) |
| Other Name | |
| Species | Human |
| Gene ID | 8821 |
| Uniprot | O15327, |
| Species.1 | Mouse |
| Gene ID.1 | 234515 |
| Uniprot.1 | Q6P1Y8, |
| Species.2 | Rat |
| Gene ID.2 | 116699 |
| Uniprot.2 | Q9QWG5 |
| Cellular Localization | |
| Tissue Expression | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate . Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles . The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival . |
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