Price range: $268.00 through $328.00
Background:
involucrin(IVL) Homo sapiens Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Involucrin |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Involucrin. AA range:536-585 |
| Specificity | Involucrin Polyclonal Antibody detects endogenous levels of Involucrin protein. |
| Gene Name | IVL |
| Protein Name | Involucrin |
| Other Name | IVL; / Involucrin |
| Species | Human |
| Gene ID | 3713 |
| Uniprot | P07476, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P48997 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Constituent of the scaffolding of the cornified envelope. |
| Tissue Expression | Keratinocytes of epidermis and other stratified squamous epithelia. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.,PTM:Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.,similarity:Belongs to the involucrin family.,subcellular location:Constituent of the scaffolding of the cornified envelope.,subunit:Directly or indirectly cross-linked to cornifelin (CNFN).,tissue specificity:Keratinocytes of epidermis and other stratified squamous epithelia., |
