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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/IRF-4/MUM1 [ABT080] mouse mAb
SKU: WM1432 Categories: ,

IRF-4/MUM1 [ABT080] mouse mAb

Ucallm_WM1432-50

Price range: $268.00 through $328.00

SKU: WM1432-50
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Product details

Background:
MUM1, also known as interferon regulatory factor 4, with a molecular weight of 50 kDa, is a nuclear transcription factor necessary for the development and activation of B lymphocytes. It can regulate the proliferation and differentiation of B cells and activate T lymphocytes. It is mainly used for the study of B-cell lymphoma. It is expressed in multiple myeloma, lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma. It can be used as a tissue derived immunophenotypic marker of B-cell lymphoma. At the same time, it is also expressed in RS cells in anaplastic large cell lymphoma, peripheral T-cell lymphoma and classical Hodgkin’s lymphoma. It is an immunophenotypic marker of malignant lymphoma, only limited to lymphocytes and melanocytes.

Specifications

Size50μL/100μL
TargetMUM1
ReactivityHuman
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)52kD
MW(Observed)52kD
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM080
ImmunogenSynthesized peptide derived from human MUM1 AA range: 350-451
SpecificityThe antibody can specifically recognize human MUM1 protein.
Gene NameIRF4 MUM1
Protein NameInterferon regulatory factor 4
Other NameInterferon regulatory factor 4; / IRF 4; / IRF-4; / Irf4; / IRF4_HUMAN; / LSIRF; / Lymphocyte specific interferon regulatory factor; / Lymphocyte specific IRF; / Lymphocyte-specific interferon regulatory factor; / Multiple myeloma oncogene 1; / MUM 1; / MUM1; / NF EM5; / NF-EM5; / NFEM5; / PU.1 interaction partner; / Sfpi1/PU.1 interaction partner; / Transcriptional activator PIP
SpeciesHuman
Gene ID3662
UniprotQ15306
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNuclear
Tissue ExpressionLymphoid cells.
Signaling_pathwayOrganismal Systems >> Immune system >> Th17 cell differentiation
Research Areas>>Th17 cell differentiation
FunctionDisease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6; 14)(p25; q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
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