Name: iPLA2γ Polyclonal Antibody
SKU: WP12858
Price: 268 USD
Availability: InStock

iPLA2γ Polyclonal Antibody

Ucallm_WP12858-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12858-100

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Product details

Background:

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015],

Specifications

Target	iPLA2γ
Reactivity	Human, Mouse
Applications	WB, IHC
MW(Calculated)
MW(Observed)	88kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human PNPLA8. AA range:691-740
Sequence
Specificity	iPLA2γ Polyclonal Antibody detects endogenous levels of iPLA2γ protein.
Gene Name	PNPLA8
Protein Name	Calcium-independent phospholipase A2-gamma
Other Name	PNPLA8; / IPLA22; / IPLA2G; / BM-043; / Calcium-independent phospholipase A2-gamma; / Intracellular membrane-associated calcium-independent phospholipase A2 gamma; / iPLA2-gamma; / PNPLA-gamma; / Patatin-like phospholipase domain-containing protein 8; / iPLA
Species	Human
Gene ID-1	50640
Uniprot	Q9NP80,
Species.1	Mouse
Gene ID-2	67452
Uniprot.1	Q8K1N1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015],
Cellular Localization	Endoplasmic reticulum membrane; Single-pass membrane protein . Mitochondrion membrane; Single-pass membrane protein . Peroxisome membrane; Single-pass membrane protein .
Tissue Expression	Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
Signaling_pathway
Research Areas
Function	Catalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,enzyme regulation:Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).,Function:Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.,similarity:Contains 1 patatin domain.,tissue specificity:Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.,
RRID