Name: IRF-4 Polyclonal Antibody
SKU: WP12870
Price: 268 USD
Availability: InStock

IRF-4 Polyclonal Antibody

Ucallm_WP12870-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12870-100

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Product details

Background:

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],

Specifications

Size	50μL/100μL
Target	MUM1
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human IRF4. AA range:281-330
Specificity	IRF-4 Polyclonal Antibody detects endogenous levels of IRF-4 protein.
Gene Name	IRF4 MUM1
Protein Name	Interferon regulatory factor 4
Other Name	IRF4; / MUM1; / Interferon regulatory factor 4; / IRF-4; / Lymphocyte-specific interferon regulatory factor; / LSIRF; / Multiple myeloma oncogene 1; / NF-EM5
Species	Human
Gene ID	3662
Uniprot	Q15306,
Species.1	Mouse
Gene ID.1	16364
Uniprot.1	Q64287
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus.
Tissue Expression	Lymphoid cells.
Signaling_pathway	Organismal Systems >> Immune system >> Th17 cell differentiation
Research Areas	>>Th17 cell differentiation
Function	Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6; 14)(p25; q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,