IRF-4 Polyclonal Antibody
Ucallm_WP12870-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
Specifications
| Size | 50μL/100μL |
| Target | MUM1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IRF4. AA range:281-330 |
| Specificity | IRF-4 Polyclonal Antibody detects endogenous levels of IRF-4 protein. |
| Gene Name | IRF4 MUM1 |
| Protein Name | Interferon regulatory factor 4 |
| Other Name | IRF4; / MUM1; / Interferon regulatory factor 4; / IRF-4; / Lymphocyte-specific interferon regulatory factor; / LSIRF; / Multiple myeloma oncogene 1; / NF-EM5 |
| Species | Human |
| Gene ID | 3662 |
| Uniprot | Q15306, |
| Species.1 | Mouse |
| Gene ID.1 | 16364 |
| Uniprot.1 | Q64287 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | Lymphoid cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Th17 cell differentiation |
| Research Areas | >>Th17 cell differentiation |
| Function | Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6; 14)(p25; q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells., |
Please login to post questions
Related products
