IRGM Polyclonal Antibody
Ucallm_WP2859-50
Price range: $268.00 through $328.00
Product details
Background:
immunity related GTPase M(IRGM) Homo sapiens This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010],
Specifications
| Size | 50μL/100μL |
| Target | IRGM |
| Reactivity | Human, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 19kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 101-150 |
| Specificity | IRGM Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | IRGM IFI1 IRGM1 LRG47 |
| Protein Name | Immunity-related GTPase family M protein (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47) |
| Other Name | |
| Species | Human |
| Gene ID | 345611 |
| Uniprot | A1A4Y4, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q6AYC2 |
| Cellular Localization | Golgi apparatus membrane . Cell membrane . Cytoplasmic vesicle, phagosome membrane . Cytoplasmic vesicle, autophagosome membrane . Cell projection, phagocytic cup . Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. . |
| Tissue Expression | Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | >>Toxoplasmosis |
| Function | Disease:Defects in IRGM are associated with susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. CD is commonly classified as an autoimmune disease. The causal variants do not affect the protein sequence but may lie in regulatory regions and alter its expression.,Function:Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.,induction:Not up-regulated by IFNG.,miscellaneous:Depletion of IRGM by siRNA favors mycobacteria survival in macrophages.,miscellaneous:There is a huge difference in terms of sequence and regulation of expression compared to the mouse ortholog and hence, the function might be slightly different (PubMed:16277747).,similarity:Belongs to the interferon-inducible GTPase family.,subcellular location:Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.,tissue specificity:Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes., |
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