Name: IRK13 Polyclonal Antibody
SKU: WP1233
Price: 268 USD
Availability: InStock

IRK13 Polyclonal Antibody

Ucallm_WP1233-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WP1233-100

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Product details

Background:

This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010],

Specifications

Size	50μL/100μL
Target	IRK13
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	39kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	IRK13 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	KCNJ13
Protein Name	Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13)
Other Name
Species	Human
Gene ID	3769
Uniprot	O60928,
Species.1	Mouse
Gene ID.1
Uniprot.1	P86046,
Species.2	Rat
Gene ID.2
Uniprot.2	O70617
Cellular Localization	Membrane; Multi-pass membrane protein.
Tissue Expression	Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord.
Signaling_pathway
Research Areas	>>Protein digestion and absorption
Function	Disease:Defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration (SVD) [MIM:193230]. SVD is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.,Function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,tissue specificity:Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord.,

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IRK13 Polyclonal Antibody

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IRK13 Polyclonal Antibody

Product details

Specifications

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