Product details
Background:
ISCU rabbit pAb
Ucallm_WP6021-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ISCU |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 18kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ISCU |
| Specificity | This antibody detects endogenous levels of ISCU at Human, Mouse |
| Gene Name | ISCU NIFUN |
| Protein Name | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein) |
| Other Name | |
| Species | Human |
| Gene ID | 23479 |
| Uniprot | Q9H1K1, |
| Species.1 | Mouse |
| Gene ID.1 | 66383 |
| Uniprot.1 | Q9D7P6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Mitochondrion .; [Isoform 2]: Cytoplasm. Nucleus . |
| Tissue Expression | Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta. |
| Signaling_pathway | |
| Research Areas | |
| Function | Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins . First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).; [Isoform 2]: Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm. |
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