Product details
Background:
ISG20 rabbit pAb
Ucallm_WP4215-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ISG20 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 20kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ISG20 AA range: 87-137 |
| Specificity | This antibody detects endogenous levels of ISG20 at Human/Mouse |
| Gene Name | ISG20 HEM45 |
| Protein Name | ISG20 |
| Other Name | |
| Species | Human |
| Gene ID | 3669 |
| Uniprot | Q96AZ6, |
| Species.1 | Mouse |
| Gene ID.1 | 57444 |
| Uniprot.1 | Q9JL16 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body. |
| Tissue Expression | Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.,cofactor:Manganese.,Function:Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.,induction:Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.,miscellaneous:Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV), influenza virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative antiviral pathway against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer lines.,similarity:Belongs to the exonuclease superfamily.,subunit:Associates with PML and SP100 in the PML NB complex.,tissue specificity:Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung., |
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