ITF Polyclonal Polyclonal Antibody
Ucallm_WP16144-50
Price range: $268.00 through $328.00
Product details
Background:
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TFF3 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA(peptide)1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ITF Polyclonal AA range: 1-50 |
| Specificity | This antibody detects endogenous levels of human ITF Polyclonal |
| Gene Name | TFF3 ITF TFI |
| Protein Name | Trefoil factor 3 |
| Other Name | Trefoil factor 3; / Intestinal trefoil factor; / hITF; / Polypeptide P1.B; / hP1.B |
| Species | Human |
| Gene ID | 7033 |
| Uniprot | Q07654, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q62395 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . Cytoplasm . |
| Tissue Expression | Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).,similarity:Contains 1 P-type (trefoil) domain.,subunit:Monomer. Homodimer; disulfide-linked.,tissue specificity:Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus., |
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