Name: U-Blot® ITGB6 Rabbit mAb
SKU: WR4244
Price: 268 USD
Availability: InStock

U-Blot® ITGB6 Rabbit mAb

Western blot analysis of lysates from Hela cells, using ITGB6 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4244 Western blot analysis of lysates from Hela cells, using ITGB6 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4244-50

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Product details

Background:This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Specifications

Size	50μL/100μL
Target	ITGB6
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	86kD
MW(Observed)	86kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:2000-1:10000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0428R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ITGB6
Protein Name	Integrin beta-6
Other Name
Species	Human
Gene ID	3694
Uniprot	P18564,
Species.1	Mouse
Gene ID.1	16420
Uniprot.1	Q9Z0T9,
Species.2	Rat
Gene ID.2
Uniprot.2	Q6AYF4
Cellular Localization	Membrane
Tissue Expression	Keratinocyte,Pancreas,Skeletal muscle,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction
Research Areas	>>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>ECM-receptor interaction; / >>Regulation of actin cytoskeleton; / >>Human papillomavirus infection; / >>Hypertrophic cardiomyopathy; / >>Arrhythmogenic right ventricular cardiomyopathy; / >>Dilated cardiomyopathy
Function	Function:Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.,