Name: KCC2G rabbit pAb
SKU: WP3952
Price: 268 USD
Availability: InStock

Product details

Background:

The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011],

Specifications

Size	50μL/100μL
Target	KCC2G
Reactivity	Human, Mouse, Rat
Applications	WB
MW(Calculated)	61kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human KCC2G AA range: 490-540
Specificity	This antibody detects endogenous levels of KCC2G at Human/Mouse/Rat
Gene Name	CAMK2G CAMK CAMK-II CAMKG
Protein Name	KCC2G
Other Name
Species	Human
Gene ID	818
Uniprot	Q13555,
Species.1	Mouse
Gene ID.1	12325
Uniprot.1	Q923T9,
Species.2	Rat
Gene ID.2	171140
Uniprot.2	P11730
Cellular Localization	Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side .
Tissue Expression	Expressed in skeletal muscle.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Organismal Systems >> Endocrine system >> GnRH signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Glioma;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas	>>ErbB signaling pathway; / >>Calcium signaling pathway; / >>cAMP signaling pathway; / >>HIF-1 signaling pathway; / >>Oocyte meiosis; / >>Necroptosis; / >>Adrenergic signaling in cardiomyocytes; / >>Wnt signaling pathway; / >>Axon guidance; / >>Circadian entrainment; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Cholinergic synapse; / >>Dopaminergic synapse; / >>Olfactory transduction; / >>Inflammatory mediator regulation of TRP channels; / >>Insulin secretion; / >>GnRH signaling pathway; / >>Melanogenesis; / >>Oxytocin signaling pathway; / >>Glucagon signaling pathway; / >>Aldosterone synthesis and secretion; / >>Cushing syndrome; / >>Gastric acid secretion; / >>Parkinson disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Amphetamine addiction; / >>Tuberculosis; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Glioma; / >>Diabetic cardiomyopathy; / >>Lipid and atherosclerosis
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,