SKU: WP12904 Categories: ,

KCNG2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12904-100
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Product details

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKCNG2
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC
MW(Calculated)
MW(Observed)51kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human KCNG2. AA range:321-370
SpecificityKCNG2 Polyclonal Antibody detects endogenous levels of KCNG2 protein.
Gene NameKCNG2
Protein NamePotassium voltage-gated channel subfamily G member 2
Other NameKCNG2; / KCNF2; / Potassium voltage-gated channel subfamily G member 2; / Cardiac potassium channel subunit; / Voltage-gated potassium channel subunit Kv6.2
SpeciesHuman
Gene ID26251
UniprotQ9UJ96,
Species.1
Gene ID.1
Uniprot.1
Species.2Rat
Gene ID.2307234
Uniprot.2Q9QYU3
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionHighly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.
Signaling_pathway
Research Areas
FunctionDomain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Function:Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.,miscellaneous:Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.,similarity:Belongs to the potassium channel family. G subfamily.,subunit:Heterodimer with KCNB1. Does not form homomultimers.,tissue specificity:Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.,
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