SKU: WP1508 Categories: ,

KCNH6 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1508-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetKCNH6
ReactivityHuman, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)109kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 230-310
SpecificityKCNH6 Polyclonal Antibody detects endogenous levels of protein.
Gene NameKCNH6 ERG2
Protein NamePotassium voltage-gated channel subfamily H member 6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Voltage-gated potassium channel subunit Kv11.2)
Other Name
SpeciesHuman
Gene ID81033
UniprotQ9H252,
Species.1
Gene ID.1
Uniprot.1
Species.2Rat
Gene ID.2
Uniprot.2O54853
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionExpressed in prolactin-secreting adenomas.
Signaling_pathway
Research Areas
FunctionAlternative products:Experimental confirmation may be lacking for some isoforms,Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3.,tissue specificity:Expressed in prolactin-secreting adenomas.,
Please login to post questions
Back to Top
Product has been added to your cart