KDM5A Polyclonal Antibody
Ucallm_WP0666-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013],
Specifications
| Size | 50μL/100μL |
| Target | KDM5A |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 185kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 720-800 |
| Specificity | KDM5A Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KDM5A JARID1A RBBP2 RBP2 |
| Protein Name | Lysine-specific demethylase 5A (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) |
| Other Name | |
| Species | Human |
| Gene ID | 5927 |
| Uniprot | P29375, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3UXZ9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleolus . Nucleus . Occupies promoters of genes involved in RNA metabolism and mitochondrial function. . |
| Tissue Expression | Epithelium,Eye,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Fe(2+).,Function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2., |
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