Name: KDM5B Polyclonal Antibody
SKU: WP2189
Price: 268 USD
Availability: InStock

KDM5B Polyclonal Antibody

Ucallm_WP2189-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP2189-100

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Product details

Background:

This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants. [provided by RefSeq, Sep 2015],

Specifications

Size	50μL/100μL
Target	KDM5B
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	169kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	KDM5B Polyclonal Antibody detects endogenous levels of protein.
Gene Name	KDM5B JARID1B PLU1 RBBP2H1
Protein Name	Lysine-specific demethylase 5B (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1)
Other Name
Species	Human
Gene ID	10765
Uniprot	Q9UGL1,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q80Y84
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).
Signaling_pathway
Research Areas
Function	cofactor:Fe(2+).,Domain:Both the JmjC domain and the JmjN domain are required for enzymatic activity.,Domain:The 2 first PHD-type zinc finger domains are required for transcription repression activity.,Function:Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7.,tissue specificity:Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and gllioblastoma. Up-regulated in breast cancer (at protein level).,

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KDM5B Polyclonal Antibody

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KDM5B Polyclonal Antibody

Product details

Specifications

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