Product details
Background:
KDM6A/UTX rabbit pAb
Ucallm_WP9007-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | KDM6A |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 154kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KDM6A/UTX |
| Specificity | This antibody detects endogenous levels of KDM6A/UTX at Human, Mouse |
| Gene Name | KDM6A UTX |
| Protein Name | Lysine-specific demethylase 6A (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) |
| Other Name | |
| Species | Human |
| Gene ID | 7403 |
| Uniprot | O15550, |
| Species.1 | Mouse |
| Gene ID.1 | 22289 |
| Uniprot.1 | O70546 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer |
| Research Areas | |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression . Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). |
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