Product details
Background:
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010],
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KERA rabbit pAb
Ucallm_WP3427-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | KERA |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KERA AA range: 26-76 |
| Specificity | This antibody detects endogenous levels of KERA at Human/Mouse |
| Gene Name | KERA SLRR2B |
| Protein Name | KERA |
| Other Name | Keratocan; / KTN; / Keratan sulfate proteoglycan keratocan |
| Species | Human |
| Gene ID | 11081 |
| Uniprot | O60938, |
| Species.1 | Mouse |
| Gene ID.1 | 16545 |
| Uniprot.1 | O35367 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . |
| Tissue Expression | Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664). |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2) [MIM:217300]. In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.,Disease:Increased expression in the stroma of keratoconus corneas. Keratoconus is a noninflammatory disease characterized by thinning and scarring of the central portion of the cornea.,Function:May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.,PTM:Binds keratan sulfate chains.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,tissue specificity:Cornea. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen., |
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