Product details
Background:
KIRREL3 rabbit pAb
Ucallm_WP8213-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | KIRREL3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 86kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KIRREL3 |
| Specificity | This antibody detects endogenous levels of KIRREL3 at Human, Mouse |
| Gene Name | KIRREL3 KIAA1867 NEPH2 UNQ5923/PRO4502/PRO19814 |
| Protein Name | Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) |
| Other Name | |
| Species | Human |
| Gene ID | 84623 |
| Uniprot | Q8IZU9, |
| Species.1 | Mouse |
| Gene ID.1 | 67703 |
| Uniprot.1 | Q8BR86 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein .; [Processed kin of IRRE-like protein 3]: Secreted . |
| Tissue Expression | Expressed in fetal and adult brain (PubMed:19012874). Also expressed in kidney, specifically in podocytes of kidney glomeruli (PubMed:12424224). Also expressed in skeletal muscle (PubMed:25488023). |
| Signaling_pathway | |
| Research Areas | |
| Function | Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. |
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