Price range: $268.00 through $328.00
Background:
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
| Size | 50μL/100μL |
| Target | KKIALRE |
| Reactivity | Human, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDKL1. AA range:281-330 |
| Specificity | KKIALRE Polyclonal Antibody detects endogenous levels of KKIALRE protein. |
| Gene Name | CDKL1 |
| Protein Name | Cyclin-dependent kinase-like 1 |
| Other Name | CDKL1; / Cyclin-dependent kinase-like 1; / Protein kinase p42 KKIALRE; / Serine/threonine-protein kinase KKIALRE |
| Species | Human |
| Gene ID | 8814 |
| Uniprot | Q00532, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8CEQ0, |
| Species.2 | Rat |
| Gene ID.2 | 314198 |
| Uniprot.2 | Q66HE7 |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Highly expressed in kidney, and to a lower extent in ovary. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Domain:The [NKR]KIAxRE motif seems to be a cyclin-binding region.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in kidney, and to a lower extent in ovary., |
