KLF7 Polyclonal Antibody
Ucallm_WP12933-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
Specifications
| Size | 50μL/100μL |
| Target | KLF7 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 41kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KLF7. AA range:171-220 |
| Specificity | KLF7 Polyclonal Antibody detects endogenous levels of KLF7 protein. |
| Gene Name | KLF7 |
| Protein Name | Krueppel-like factor 7 |
| Other Name | KLF7; / UKLF; / Krueppel-like factor 7; / Ubiquitous krueppel-like factor |
| Species | Human |
| Gene ID | 8609 |
| Uniprot | O75840, |
| Species.1 | Mouse |
| Gene ID.1 | 93691 |
| Uniprot.1 | Q99JB0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The acidic N-terminal part may favor interaction with the basic domain of transcription factors.,Function:Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo., |
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