KLHL12 Monoclonal Antibody
Ucallm_WM0282-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Specifications
| Size | 50μL/100μL |
| Target | KLHL12 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 63kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 13B6 |
| Immunogen | Purified recombinant fragment of human KLHL12 expressed in E. Coli. |
| Specificity | KLHL12 Monoclonal Antibody detects endogenous levels of KLHL12 protein. |
| Gene Name | KLHL12 |
| Protein Name | Kelch-like protein 12 |
| Other Name | KLHL12; / C3IP1; / Kelch-like protein 12; / CUL3-interacting protein 1; / DKIR homolog; / hDKIR |
| Species | Human |
| Gene ID | 59349 |
| Uniprot | Q53G59, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BZM0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic vesicle, COPII-coated vesicle . |
| Tissue Expression | Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The BTB domain is required for interaction with CUL3.,Function:Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.,tissue specificity:Highly expressed in testis and at lower levels in the submandibular salivary gland., |
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