KLHL13 Monoclonal Antibody
Ucallm_WM0283-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Specifications
| Size | 50μL/100μL |
| Target | KLHL13 |
| Reactivity | Human |
| Applications | WB, IHC, IF, FC, ELISA |
| MW(Calculated) | 74kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 14A2 |
| Immunogen | Purified recombinant fragment of human KLHL13 expressed in E. Coli. |
| Specificity | KLHL13 Monoclonal Antibody detects endogenous levels of KLHL13 protein. |
| Gene Name | KLHL13 |
| Protein Name | Kelch-like protein 13 |
| Other Name | KLHL13; / BKLHD2; / KIAA1309; / Kelch-like protein 13; / BTB and kelch domain-containing protein 2 |
| Species | Human |
| Gene ID | 90293 |
| Uniprot | Q9P2N7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q80TF4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | midbody,Cul3-RING ubiquitin ligase complex, |
| Tissue Expression | Brain,Testis,Thalamus,Whole embryo, |
| Signaling_pathway | |
| Research Areas | >>Ubiquitin mediated proteolysis |
| Function | Function:Substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Forms a complex with CUL3 and KLHL9. Interacts with AURKB. Interacts with CUL3., |
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