KMT2C rabbit pAb
Ucallm_WP7279-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | KMT2C |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 540kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KMT2C |
| Specificity | This antibody detects endogenous levels of KMT2C at Human |
| Gene Name | MLL3 HALR KIAA1506 KMT2C |
| Protein Name | Histone-lysine N-methyltransferase MLL3 (Homologous to ALR protein) (Lysine N-methyltransferase 2C) (KMT2C) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) |
| Other Name | |
| Species | Human |
| Gene ID | 58508 |
| Uniprot | Q8NEZ4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BRH4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) . Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place . Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements . |
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