KPCD3 Polyclonal Antibody
Ucallm_WP2286-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015],
Specifications
| Size | 50μL/100μL |
| Target | KPCD3 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 97kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | KPCD3 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | PRKD3 EPK2 PRKCN |
| Protein Name | Serine/threonine-protein kinase D3 (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) |
| Other Name | |
| Species | Human |
| Gene ID | 23683 |
| Uniprot | O94806, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8K1Y2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Membrane . Translocation to the cell membrane is required for kinase activation. |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway |
| Research Areas | >>Rap1 signaling pathway; / >>Aldosterone synthesis and secretion; / >>Chemical carcinogenesis - reactive oxygen species |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. Upon diacylglycerol-activation, phosphorylates a range of cellular proteins. Also serves as the receptor for phorbol esters, a class of tumor promoters.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,tissue specificity:Ubiquitous., |
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