Price range: $268.00 through $328.00
Background:
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012],
| Size | 50μL/100μL |
| Target | KVβ.3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KCNAB3. AA range:293-342 |
| Specificity | KVβ.3 Polyclonal Antibody detects endogenous levels of KVβ.3 protein. |
| Gene Name | KCNAB3 |
| Protein Name | Voltage-gated potassium channel subunit beta-3 |
| Other Name | KCNAB3; / KCNA3B; / Voltage-gated potassium channel subunit beta-3; / K; / +; / channel subunit beta-3; / Kv-beta-3 |
| Species | Human |
| Gene ID | 9196 |
| Uniprot | O43448, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P97382, |
| Species.2 | Rat |
| Gene ID.2 | 58981 |
| Uniprot.2 | Q63494 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.,Function:Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.,similarity:Belongs to the shaker potassium channel beta subunit family.,subunit:Forms heteromultimeric complex with alpha subunits.,tissue specificity:Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle., |
