Price range: $268.00 through $328.00
Background:
lamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
| Size | 50μL/100μL |
| Target | Lamin B1 |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IF |
| MW(Calculated) | |
| MW(Observed) | 68kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500; IF 1:200-1:1000; |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 19A3 |
| Immunogen | Recombinant human Lamin B1 protein. |
| Specificity | This antibody detects endogenous levels of Lamin B1 and does not cross-react with related proteins. |
| Gene Name | LMNB1 |
| Protein Name | Lamin-B1 |
| Other Name | ADLD; / lamin B1; / Lamin-B1; / LMN; / LMN2; / LMNB; / Lmnb1; / LMNB1_HUMAN; / MGC111419; / OTTHUMP00000159218. |
| Species | Human |
| Gene ID | 4001 |
| Uniprot | P20700, |
| Species.1 | Mouse |
| Gene ID.1 | 16906 |
| Uniprot.1 | P14733, |
| Species.2 | Rat |
| Gene ID.2 | 116685 |
| Uniprot.2 | P70615 |
| Cellular Localization | Nucleus lamina . |
| Tissue Expression | Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis |
| Research Areas | >>Apoptosis |
| Function | Disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,Function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.,PTM:B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with lamin-associated polypeptides IA, IB and 2., |
