Price range: $268.00 through $328.00
Background:
This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016],
| Size | 50μL/100μL |
| Target | LAP1B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 66kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TOR1AIP1. AA range:431-480 |
| Specificity | LAP1B Polyclonal Antibody detects endogenous levels of LAP1B protein. |
| Gene Name | TOR1AIP1 |
| Protein Name | Torsin-1A-interacting protein 1 |
| Other Name | TOR1AIP1; / Torsin-1A-interacting protein 1; / Lamin-associated protein 1B; / LAP1B |
| Species | Human |
| Gene ID | 26092 |
| Uniprot | Q5JTV8, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q921T2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus inner membrane; Single-pass membrane protein . |
| Tissue Expression | Expressed in muscle, liver and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TOR1AIP family.,subunit:Interacts with TOR1A., |
